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There is also some evidence to suggest that exposure to titanium dioxide nanoparticles may be harmful or toxic to the environment, including aquatic life and other organisms. The production and disposal of the mineral may also release pollutants, such as carbon dioxide and sulfur dioxide, into the air and water.

Of the products that include the additive in their labels, Thea Bourianne, senior manager at data consultant Label Insights, told Food Navigator USA in May 2021 that more than 11,000 products in the company's database of U.S. food and beverage products listed titanium dioxide as an ingredient. Non-chocolate candy led those numbers at 32%. Cupcakes and snack cakes made up 14%, followed by cookies at 8%, coated pretzels and trail mix at 7%, baking decorations at 6%, gum and mints at 4% and ice cream at 2%.

The application of lithopone in building materials industry can not only be used as water-soluble coatings for interior and exterior walls of buildings, but also as fillers for wallpaper, floor paint, dining table and other plastic all ceramic veneers.

In the same year (2019), the Netherlands Food and Consumer Product Safety Authority (NVWA) also delivered an opinion on possible health effects of food additive titanium dioxide, which highlighted the importance of examining immunotoxicological effects in addition to potential reprotoxicological effects.

We've used titanium dioxide safely for decades. However, recently its safety was called into question. 
 
At CRIS, we've explored the safety of titanium dioxide for nearly half a decade, including conducting double-blind research to test the safety of food-grade titanium dioxide (E171). Our study shows that when exposed to food-grade titanium dioxide in normal conditions, research animals did not experience adverse health outcomes.
 
It's important to emphasize that in a National Institutes of Health study, experimental animals were exposed to titanium dioxide in amounts as high as 5% of their diet for a lifetime and showed no evidence of adverse effects. 
 
A handful of studies greatly influenced the decisions made by the European Food Safety Authority (EFSA). Unfortunately, these studies did not consider that titanium dioxide exposure comes from food, not drinking water. Additionally, CRIS researchers could not reproduce the adverse outcomes identified by the studies through typical food ingestion. Regardless, the EFSA banned E171 as a food ingredient and for use in other capacities in the summer of 2022.
 
In 2022, the United States, United Kingdom, and Canada maintained that the scientific evidence supports that titanium dioxide (E171) is safe for humans to use and consume.

In addition to its aesthetic benefits, lithopone also offers practical advantages for leather suppliers. Due to its low cost and wide availability, lithopone is a cost-effective option for leather manufacturers looking to minimize production expenses without compromising on quality. Its stable chemical properties also make it easy to work with during the manufacturing process, resulting in a smooth and efficient production line.

The properties of lithopone are very suitable for use in the production of coatings. Because the ingredients of lithopone are zinc sulfide and barium sulfate, and the more zinc sulfide content, the stronger its covering power. This indicates a paint product with strong white covering power. It is different from water in that it reacts with acid but does not react with alkali. It has a wide range of uses. Because its structural properties are similar to titanium dioxide and its price is relatively cheap, it can also be used as a substitute for some titanium dioxide. Lithopone can be used for coloring paints, inks, pigments, rubber, paper, leather, enamel, etc.

That being said, most experts tell us that these potential health risks shouldn’t trouble us, because titanium dioxide has been used in the market for decades, and no adverse reactions have been reported by users. The bottom line is that when used correctly, titanium dioxide should be a safe ingredient that’s safe for all skin types, every day